IUBio

Brain clues to attention disorder

orkeltatte at hotmail.com orkeltatte at hotmail.com
Sun Dec 21 13:37:18 EST 2003


Dave Bird <dave at nospam.xemu.demon.co.uk> wrote in message news:<MdRByNADua5$EwsC at xemu.demon.co.uk>...
> In article<84da9680.0312210247.4030f84b at posting.google.com>,
> orkeltatte at hotmail.com <orkeltatte at hotmail.com> writes:
> >> >The fact that Ritaline and other similar central stimulating drugs has 
> >> >the paradoxal effect of normalizing activity and attention in ADDH 
> >> >conditions , 
> >> 
> >> It is only paradoxical if we play a bit of word magic with 'stimulating'
> >
> >Sorry! But this is semantic bullshit.Paradoxal refers to an opposite 
> >effect compared to the common effect on the majority of people - eg 
> >excitatory, increased psychomotor tempo and activity and soforth.
> 
>  Let me explain.  The effect is not ACTUALLY paradoxical if we
>  examine carefully.  There is only an APPARENT paradox if we 
>  carelessly use the word 'stimulant'  without specifying 'of what'.
> 
>  "The fact that a (reflection-) stimulating drug abates a
>  (movement-) stimulating disorder is APPARENTLY paradoxical
>  until we realise that they stimulate different and opposing factors"
> 
Still playing with words
> 
>  I would reserve the word paradoxical when it genuinely the
>  same quantity involved: "how is it that a patient with HIGH DOPAMINE is
>  clearly showing and EXTRA-PYRAMIDAL TREMOR  from low dopamine effect?";
>  "how is it that problems which began with RAISED SEROTONIN are now
>  cleared up by INCREASING SEROTONIN LEVELS?"; etc.

That will probably be due to the effect of up - and downregulationg of
the receptors in question - adapting, or trying to adapt to new
neurochemical environment



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