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Protein Structure.

Qinghong Zeng beaglesci at yahoo.com
Sat Mar 30 01:58:42 EST 2002


hi,
Very sorry,I just get your reply from
http://tantalum-e2.hgmp.mrc.ac.uk/hypermail/neur-sci/neur-sci.200112/0098.html,it
is really too late.
If you have interesting proteins and they can be
expressed solubly in E.coli, please contact with me.
Perhaps their stuctures will tell you surprising
things.
Best wishes!
Very sincerely, yours 
beagle


beaglesci at yahoo.com 




Subject: RE: Protein Structure.
From: Anderson, John (JEANDERS at unf.edu)
Date: Sun 30 Dec 2001 - 17:55:31 GMT 


Next message: Tech Support: "Get Profe$$ional Tech
$upport with thi$ Opportunity!!!" 
Previous message: dag.stenberg at nospam.helsinki.fi:
"Re: Protein Structure." 
Maybe in reply to: Qinghong Zeng: "Protein Structure."

Maybe reply: Anderson, John: "RE: Protein Structure." 

--------------------------------------------------------------------------------

> -----Original Message----- 
> From: dag.stenberg at nospam.helsinki.fi 
> [mailto:dag.stenberg at nospam.helsinki.fi] 
> Sent: Saturday, 29 December 2001 13:30 
> To: neur-sci at hgmp.mrc.ac.uk 
> Subject: Re: Protein Structure. 
> 
> 
> Qinghong Zeng <beaglesci at yahoo.com> wrote: 
> > My major is Structural Biology, and our lab has
good 
> > facilities to solve protein structures by X-ray.
But 
> > now I am short of some proteins which are
potentially 
> > important to study. If you are working at the
study of 
> > some protein¡¯s functions and interested in its 
> > structure, please don¡¯t hesitate to contact with 
> > me.If the protein can be expressed in E.coli and
is 
> > soluble,it will be good news to our collaboration.

> 
> I do not get the idea in this posting at all. 
> Do I understand that this guy wants to solve protein

> structures but has 
> no idea what to solve? And wants us, the world, to
send him 
> problems to 
> solve. He seems to imply that they can produce the
protein under study 
> in E.coli to get enough to crystallize and then find
the structure of. 
> 
> I am very surprised because I happen to have
contacts with a 
> guy who has 
> been working on one multi-domain protein for a
number of years, and is 
> not complaining about lack of ideas what to study,
but about how the 
> structure still partially eludes them. He does not
lack a problem, he 
> lacks the final solution. 


Speaking as a former macromolecular crystallographer,
I don't think you 
should be too surprised. There are two types of
crystallographers: those who 
use crystallography as a tool to study molecules they
are interested in, and 
those who use any available molecule, hopefully of
some interest to 
somebody, to develop crystallographic techniques.
Sounds like your 
acquaintance is one of the former, and Qinghong Zeng
is one of the latter. 
Zeng might be from China where there could very well
be a shortage of 
suitable proteins. It actually seems to me to be a
very good way to scare 
up an interesting problem. 


> So, beaglesci, what do you really want to do? If
somebody has 
> a problem, 
> would you do it (any problem) for them even if it
takes 2-3 
> years? 


I imagine Zeng would answer yes. 


John Anderson, PhD 
Department of Chemistry & Physics 
University of North Florida 
4567 St Johns Bluff Road South 
Jacksonville FL 32224 
USA 
jander at unf.edu 




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