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Mechano-sensitive AND voltage-gated channels

Edmund Müller edmund.mueller at freenet.de
Mon Mar 25 01:04:59 EST 2002


Hallo NG,

I have some strange experimental results, which could be explained if
there were something like ion channels which are membrane voltage gated
AND mechano-sensitive at the same time.

I mean is it possible that mechanical stress on the cell membrane, like
a pipette in cell-attached, could lead to the opening of more
voltage-gated channels underneath the patch with the same given voltage
step than normally? That way that the conductance could be something
like 5 - 10 fold for that little peace of membrane?

Excuse the maybe simple question, I'm a technician, not a physiologist.
And have to do this diploma thesis by next tuesday.

Thnx Edmund




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