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Information on BBB permeability

yan king yin (dont spam) y.k.y at lycos.com
Tue Mar 12 13:53:21 EST 2002

There is a chapter on the BBB in the book "Basic Neurochemistry"
edited by Siegel et al (1999). I think it is very up-to-date and a good
intro. There is also a chapter about molecular aspects of MS in the

Also I guess you would like to check out some books on
neuroimmonology, because T-cells, B-cells, and monocytes (and
probably some other immune cells) can also cross the BBB in
normal and pathological conditions, and this is obviously relevant
to MS. Im reading "Immunology of the Nervous System" edited
by Keane and Hickey (1997).

If you are interested in peptides (and some other smaller molecules
and hormones) there is "The BBB, Amino Acids and Peptides" by
Segal and Zlokovic (1990).

Thats about all that I can find about the BBB. I havent searched
the journals yet.

By the way, do you have a medical degree? Im interested in doing
clinical research and am wondering if an MD is required for it.

"Derek Soon" <d.soon at ion.ucl.ac.uk>
> I am starting a 3 year research post at the NMR unit, Institute of
> Neurology,
> Queen Square. As part of my research, I would like to look at blood
> brain
> barrier changes in MS more closely. As I have only started my research
> project,
> I am a relatively ignorant about our current understanding of the
> blood brain
> barrier, and I was wondering whether anyone would be able to suggest
> any good sources of information which would bring me up to date with
> regards to our understanding of what constitutes the normal blood
> brain barrier, (both structurally and biochemically) and what attempts
> have been made for quantifying the permeability of the barrier. I look
> forward very much to hearing from you.

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