I,
If you talk about the phamtom pain or any phenomenom in relation with, we
can considerate two level.
first, on the cns : the region where's incoming information is depletated in
information but neurons are still firing and the neurons of the peripheric
area are invading the place. (you can refer to the experience of monkeys
with two fingers attached)
second, on the pns : you must say first that if a neuron in place lost his
connection with his targeted tissue or cell, he dies. That's why many
neuron's are lost on amputating case and that's why too the burn person if
they reintegrate a sensation on the burned zone, connection are incomplete
and not so much functional. In this case, peripheral neurons of the lesional
area colonized this region but not in an "appropriate way".
I'm not sure to answer to your question but I think you may explore this
way.
yannick
"Mark Zarella" <NOmarkzarellaSPAM at attbi.com> a écrit dans le message news:
t_JZ8.243749$Uu2.52221 at sccrnsc03...
> > Even after rereading the analgesia chapter in Kandel, I'm having trouble
> > understanding the mechanism in which the sensation of pain can be
> > experienced in areas where there's no other sensory activity. For
> instance,
> > if a peripheral nerve is severed and a limb or digit then becomes numb
to
> > all forms of sensory activity, how then can pain still be detected in
> these
> > areas?
>> To further clarify this paragraph, I'm not referring to pain as a result
of
> a stimulus, but rather "randomized" pain, similar to an amputee's "phantom
> pain".
>>
