I thought readers of bionet.neuroscience might be interested in this
book. For more information, please visit
http://mitpress.mit.edu/0262072297/ Thank you!
Best,
David
Microarrays for the Neurosciences
An Essential Guide
edited by Daniel H. Geschwind and Jeffrey P. Gregg
The effort to sequence the human genome has generated a new discipline,
"functional genomics," or the study of the relationship between the
genetic code and its biologic potential. Gene expression studies are
made possible not only by the decoding of the human genome, but by the
development of new technologies. The preeminent technology in this area,
DNA microarrays, is helping to revolutionize the field of neuroscience.
Rather than looking at one gene at a time, researchers using DNA
microarrays can monitor the expression patterns of large numbers of
genes simultaneously. Bridging the traditional gap between molecular
neurobiology and systems neurobiology, DNA microarray technology has the
potential to elevate molecular genetic studies of the nervous system to
the system level.
This book provides a comprehensive guide to the use of DNA microarrays
in neuroscience and provides approaches that are applicable to other
complex biological systems. Human nervous system tissue is remarkably
complex. The number of cell types, the architecture, the developmental
program, and the importance of environmental factors in development and
functioning all pose particular challenges to the researcher using gene
expression studies. After an overview of the technology, the book
discusses array scanning and image application, statistical methods for
array analysis, specific applications of gene expression studies in the
central nervous system, the use of postmortem human tissue, and novel
methods for using microarray data to develop hypotheses about regulatory
networks.
Daniel H. Geschwind is Assistant Professor of Neurology and Director of
the Neurogenetics Program at the University of California at Los Angeles
School of Medicine. Jeffrey P. Gregg is Assistant Professor of Pathology
and Director of Molecular Pathology at the University of California at
Davis School of Medicine.
7 x 9, 288 pp., 75 illus., 8 color, cloth, ISBN 0-262-07229-7
Cellular and Molecular Neuroscience series
A Bradford Book
