IUBio

Direction of travel along axon?

Theophilus Samuels theophilus.samuels at btinternet.com
Sat Oct 21 15:35:47 EST 2000


  NGF is taken up at the nerve terminals and transported back to the cell
body - retrograde transport. Interruption of this transport blocks the
effects of NGF and results in the death of neurons that are dependent on its
effects. NGF stimulates dimerisation and autophosphorylation of the TrkA
receptor and initiation of intracellular signalling cascades that propagate
the signal to the nucleus. When the pheochromocytomaderived cell line PC12
is exposed to NGF, CREB becomes phosphorylated on its regulatory site
Ser133, and this phosphorylation event promotes NGF activation of
transcription of the immediate early gene c-fos. Many NGF-regulated
immediate early genes and delayed-response genes contain CREB binding sites
within their upstream regulatory regions, therefore CREB is likely to be a
mediator of the general nuclear response to neurotrophins.
  Read the paper by Riccio et al. in the August 1997 edition of Science (I
forget its exact title).

T.L.S.

Richard Norman <rsnorman at mediaone.net> wrote in message
news:9JhI5.2032$EA6.137446 at typhoon.mw.mediaone.net...
> "mike" <mike-anderson at nwu.edu> wrote in message
> news:mike-anderson-2110000251100001 at dhcp083174.res-hall.nwu.edu...
> > i am confused as to the direction that different molecules travel along
> > the axon, i know that organelles can be carried antero, or retrograde,
but
> > what about things such as nerve growth factor?  Just a little confused.
> > Forgive me if this is the wronog place to ask.
> > --
> > mike
> > In my dreams i'm dying all the time
> > http://www.mp3.com/mikeanderson
>
> This is a good place to ask.  I believe it is possible for pretty much
> anything
> inside the neuron to be carried in any which direction.  What is more to
the
> point is where is the stuff likely to come from?
>
> If a cell is manufacturing a protein, then that must be done in the rough
> ER in the soma.  Therefore it will be transported anterograde down the
> axon.  On the other hand, if a protein is made somewhere else outside
> the cell and acts as a signaling agent, then it is possible for it to be
> picked up by endocytosis and transported.  So something that is picked
> up at the axon terminal (where the vesicle recycling allows for a lot of
> that
> kind of thing) might well be transported retrograde back to the cell body
> Something picked up in the soma or dendrite area might be transported
> anterograde down the axon.
>
> I don't know specifically where nerve growth factor fits in the story.
>
> And I would suggest you talk to someone about your dreams!
>
>
>







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