IUBio

Resting "leak" ion channels

Richard Norman rsnorman at mediaone.net
Wed Oct 27 07:03:08 EST 1999


Yes, glia have such channels.  But do those channels have the same
structure, belong
to the same protein families, as the gated channels?

ken collins wrote in message
<19991026205649.26112.00001303 at ng-bj1.aol.com>...
>search the Glia literature.
>glia redistribute ion concentrations, thereby, yielding ionic
concentrations
>within the ranges of gated channels, thereby, rendering the 'gatedness' not
>all-there-is.

>>From: "Richard Norman" rsnorman at mediaone.net
>>
>>Are the ion channels normally open at rest, and responsible for the "leak"
>>currents as well as the resting potential, related to the gated channels
>>responsible for action, synaptic, and receptor potentials?
>>
>>I always thought not, arguing that all cells have a resting Na, K, and Cl
>>permeability but usually not gated channels. Dendrites and axons alike
have
>>leaks, as do cells neurons that are not electrically excitable at all.
>>
>>In looking deeper, I find references to the "fact" that "all ion channels
>>are gated", with stable open and closed states.  However, I cannot find
any
>>specific mention of the channel type that corresponds to the resting leak.
>>
>>Do you have any references?






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