In article <dotoole-0510991343000001 at bio200091.bio.tcd.ie>, Dan-solo
<dotoole at NOSPAM!tcd.ie> writes
>>In article <7t9fd4$4cq at news.acns.nwu.edu>, "MJ Lee" <mjlee at nwu.edu> wrote:
>>>>Can blood cells pass through BBB and enter the cerebrospinal fluid?
>>thanks!
>>>.
>Blood resident lymphocytes can break through the BBB during a Multiple
>Sclerosis relapse, where they are directed to inflammation sites by IL-10.
>I don't think this normally ever happens though. As far as I know,
>macrophages can do the same thing. I'd imagine that any oxygen required by
>the neuron is provided via the astrocyte, as there are no RBCs in CSF.
Any inflammatory (eg MS, cerebral vasculitis) or infective (eg
meningitis, encephalitis) process involving brain and/or meninges can
cause white blood cells to appear in CSF. Red cells appear in CSF when
there is subarachnoid haemorrhage. But in normal healthy individuals
there are no blood cells in CSF.
--
Nick Medford
