Apparently, Ken has as much trouble reading English as the rest of us
have reading his language, whatever it is.
A quick look at John's brief quote is sufficient to show that Ken
missed the point entirely. Nobody "induced and [sic] 'LTP'-like
condition" in THIS experiment. This was a study of mice who are
LACKING in the ability to develop LTP.
Starting from ignorance and confusion, using terms which perhaps even
HE doesn't understand, courageously following the disorderd twists and
turns of his own thought, it's no wonder that he produces such a
marvelous specimen as what follows that innocent revelation of his
mis-reading.
F. LeFever
In <eOjri1#1#GA.134 at cpmsnbbsa03> "Ken Collins" <KPaulC at email.msn.com>
writes:
>>the press release didn't provide sufficient info, but simply inducing
and
>'LTP'-like condition indiscriminantly with respect to the
>topologically-distributed nature of 'normal' nervous system function,
does
>not eliminate all of the trophic consequences inherent in the
>non-interfered-with resultant activation 'state', and if there's
enough
>information remaining in the resultant activation 'state' to allow the
TD
>E/I-minimization mechanisms to achieve convergence upon a supersystem
>configuration, the nervous system ('brain') does exactly that, and an
>'appropriate' behavioral response is 'addressed' via the TD
E/I-minimization
>with respect to what's left, 'after' the experimental stuff is
'applied'.
>>within the tightly-integrated neural topology, the forced,
>indiscriminant-of-the-TD, 'LTP'-like condition, in fact, constitutes a
>relatively-random activation sub-'state'... a TD E/I(up)
sub-'state'... and
>any remaining (non-interfered-with) TD E/I-minimization mechanisms
just
>'whittle' (AoK, Ap5) it away, as they 'normally' do with with other
>superfluous (relatively-random) activation.
>>it's been a major shortcoming of most experiments in Neuroscience that
the
>tight mapping of the neural topology has been largely ignored... if an
>experimental design is not engineered in a way that keeps the Topology
of
>the experimental part commensurate with the innate neural Topology,
then, to
>the degree of such, the experiment yields False results.
>>K. P. Collins
>>John wrote in message <933043969.298961 at server.australia.net.au>...
>>>>"There still remains, however, one unresolved and very controversial
issue:
>>To what extent does long-term potentiation participate in learning
and
>>memory acquisition? Contrary to their expectations, the scientists
from
>>Heidelberg could not demonstrate abnormal learning behaviour in the
mutant
>>mice. Rather, the mice lacking LTP were, like normal mice, capable of
>>accurately finding a submerged, invisible platform in a pool of murky
water
>>("water maze") and to swim there immediately when placed in the
water."
>>>>>>>>>>>>http://www.eurekalert.org/releases/mpg-dal060299.html>>>>>>
