i knew it was glutamate all along, Frank, but glutamate was referenced in
one of the refs i read in response to the work John's doing... so, since
folks knew i was 'over-there', i didn't bother.
my earlier ref to kainic acid was a reference back to a series of
presentations i gave at Smith College back in the 80s.
excitotoxicity is excitotoxicity... the nervous system 'moves away from'
such... glutamate is in-there, but it's normally well-controlled, except
when lesions disrupt the intact mechanism, as in strokes or epilepsy.
all of this is in AoK, Frank, if you'd 'just' =Think=, instead of 'moving
away from'...
...guess AoK's just a bit to 'exciting' for you to deal with :-)
K. P. Collins
F. Frank LeFever wrote in message <7nokep$cvf at dfw-ixnews6.ix.netcom.com>...
>>Maybe I should put it more simply: it is really not relevant whether
>10% or 100% of all the known and unknown neurotransmmitters are "in"
>AoK, implicitly or explicitly; the point is, you do not have the most
>basic UNDERSTANDING of them, and by your foolish rush to say something
>you thought was relevant demonstrated that you do NOT know WHICH
>excitatory amino acid is involved in NATURALLY OCCURING neurotoxic
>reacttions due to seizure, stroke, or mechanical trauma.
>>By now, you should have had time to look it ups. (NOT in AoK, of
>course; but if you think it's in there, by all means look again; if you
>find it, tell us what it is.)
>>F. LeFever
>>>>In <utVGgqy1#GA.421 at cpmsnbbsa02> "Ken Collins" <KPaulC at email.msn.com>
>writes:
>>>>i stand on what i posted...
>>>>every neuro-active substance that exists, or which can be artificially
>>synthesized, is thoroughly discussed in AoK.
>>>>K. P. Collins
>>>>F. Frank LeFever wrote in message
><7ngk0i$j3e at dfw-ixnews14.ix.netcom.com>...
>>>>>>What a pathetic clutching at a pretense of knowing something:
>>>"implicit", oh, yeah...
>>>>>>You would have been better off if you had left it implicit, but
>>>NO-o-o-o: you had to throw in a word you had read somewhere (as
>usual,
>>>without understnding the context at all). At about the time you
>>>stopped reading, kainic acid was all the rage for EXPERIMENTALLY
>>>INDUCED lesions, but surely you MUST know (QUICK, re-read AoK, it
>MUST
>>>be in there SOMEWHERE--maybe next to the missing fornix section?),
>MUST
>>>know that when people are talking about ENDOGENOUS OVERPRODUCTION due
>>>to seizure or stroke or trauma. they are talking about SOME OTHER
>>>excitatory amino acid; one which is very important in normal
>>>functioningf; indeed, one which is the neurotransmitter in perhaps
>90%
>>>of the brain's synapses (well, don't flame me if I am off by 1 or 2
>>>percentt).
>>>>>>Enough hints? I won't say whatt it is until you've had a chance to
>>>look it up and post it and say "I knew that!"
>>>>>>F. LeFever
>>>>>>>>>>>>>>>In <uVk4xnk1#GA.252 at cpmsnbbsa05> "Ken Collins" <KPaulC at email.msn.com>
>>>writes:
>>>>>>>>'excitotoxins'... chemically-induced rampant TD E/I(up, up)... as in
>>>'kainic
>>>>acid'.
>>>>>>>>it's all (implicit) in AoK, Frank.
>>>>>>>>ken collins
>>>>>>>>F. Frank LeFever wrote in message
>>><7nd3lg$o5a at dfw-ixnews4.ix.netcom.com>...
>>>>>>>>>[...]
>>>>>>>>>Knowing personally someone who has played a very important role in
>>>>>establishing the role of excitotoxins in hippocampal damage due to
>>>>>seizure, and giving considerable attention to the role of
>>>excitotoxins
>>>>>(i.e. over-produced excitatory amino acid transmitters) in other
>>>>>conditions (stroke, head trauma),
>>>>>>>>>[...]
>>>>>>>>>>>>>>>>
