IUBio

Functional Multiplexing - AoK, Ap9

Ken Collins KPaulC at email.msn.com
Tue Jul 27 14:42:13 EST 1999


whoops! ...missed one.

I RETRACT THIS EARLIER POST OF MINE... i've already explained elsewhere.

K. P. Collins

Ken Collins wrote in message ...
>for an example of 'functional multiplexing', as it's discussed in AoK, Ap9,
>see:
>
>http://www.eurekalert.org/releases/mgh-rfm072099.html
>
>from the press release:
>
>"Two things are curious about the identification of a cyptochrome as an
>essential part of a negative feedback loop in the inner workings of the
>mammalian clock. One is that its role could never have been predicted based
>on the structure of the protein itself. Cryptochromes are a family of
>light-sensing proteins. Who would have guessed that such a protein would
>function in a light-independent manner to regulate per? The second curious
>aspect of the finding is that cryptochromes play an entirely different (and
>more predictable) role in regulating the rhythms of plants and flies where
>they form the critical light sensors that reset the biological clock in
>response to light. Just as a Rolex keeps time according to its own inner
>machinery and yet can be reset to a new time zone by a turn of a knob, so
>too can the intrinsic machinery of the biological clock be reset by light.
>The identification that the resetting knob of one clock makes up part of
the
>inner workings of another is certainly surprising and unprecedented."
>
>False and False... as is explained in AoK.
>
>K. P. Collins
>
>





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