IUBio

Neurotransmitter Release ?

Carl Molander Carl.Molander at neuro.ki.se
Sun Jan 31 09:19:08 EST 1999


Hi Gerth,
    I think many would agree with me that your second question about "pain
transmittor" is based on a misunderstanding of the meaning of the word
"pain". Pain is a personal experience, a perception based on a number of
factors: nociceptive input, other sensory input, previous experience, state
of fear, etc. This experience, in the sense it should be used, could hardly
be perceived by one neurone alone. I think a better word for what I think
you have in mind may be  "nociceptive signal" which means a neuronal signal
that informs the brain that a certain part of the body is exposed to a
stimulus which is harmful or potentially harmful. This signal may, or may
not, be interpreted by the individual as pain.
    As for the sensory nerve fibers that convey nociceptive signals, a
number of transmitters and "modulators" have been demonstrated: glutamate,
substance P, NKA, calcitonin gene related factor....

Try International Association for the Study of Pain (IASP)
http://www.halcyon.com

Best wishes,

Carl


Gerthory Toussaint skrev i meddelandet <36ADF792.64C8EC44 at idi.ntnu.no>...
>Hello All,
>
>    I would like to ask you a question about the release of
>neurotransmitter. Does it possible for a neuron to release several
>different type a neurotransmitter a the same time ? I read that neurons
>have several transmitter. Can someone tell me if this mechanism is based on
>the frequency of the input signal/the area of the brain which is excited or
>both ?
>
>    By the way, is it possible for a neuron to distinguish a pain signal ?
>(does they release a special neurotransmitter ?)
>
>Thank you very much for any answer which can help me.
>--
>Gerth
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