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Nerve Cells with Stoppage: Evidence for a molecular key step in the process of signal transduction between nerve cells

John johnhkm at netsprintXXXX.net.au
Tue Aug 3 05:09:25 EST 1999

By eliminating a single synaptic protein, German and US-american researchers
provide the first direct evidence that vesicles, which act as cellular
transporters, underlie a maturation process making them competent for
membrane fusion in the context of neurotransmitter release at nerve cell
synapses (Nature, 29 July 1999)."

"Interestingly, this role of Munc13-1 is specific for synapses using the
excitatory neurotransmitter glutamate. Other synapses appear to function
independently of Munc13-1, indicating the existence of transmitter-specific
vesicle maturation processes."

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