Thanks for the Refs... I'll look up your work... will take some doing because
I've no easy-access to a University Library these days... but I'll do it
because it sounds as Interesting as anything I've ever read.
(I should explain... when all the work I did was just brushed-aside 10-15
years ago, I "gave-up" reading in the Neuroscience stacks... it just Hurt
too-much to continue... but I'll give the Refs you've cited a read, and I
expect I'll be able to move their Stuff "center-stage, immediately.)
Thanks, again, Stephen. ken collins
Stephan Anagnostaras wrote:
> In article <73qeta$lj8 at dfw-ixnews4.ix.netcom.com>,
>flefever at ix.netcom.com(F. Frank LeFever) wrote:
>> > Even a clock that is no longer running will be exactly right twice a
> > day.
> >
> > Apparently kkollins is correct: the program does seem to have
> > included a segment on Eric Kandel's work (as well as another segment,
> > on the famous patient HM; I mention this because kkollins clipped this
> > from the original post, leaving the rest of my comment mysterious to
> > those who did not see it).
> >
> > I say apparently, because I have not seen a response from anyone
> > explicitly saying that he saw the program and can verify this; but the
> > surmise (by another respondent) that what was heard as "kreb" was
> > actually CREB seems reasonable.
> >
> > For kkollins not to comment on the unlikelihood that Eric Kandel would
> > be talking about the Krebs cycle in rodents, however, suggests that his
> > knowledge of Kandel's work is nil, and he is just one of thousands
> > millions?) who have heard or seen Kandel's name over the past 2-3
> > decades.
> >
> > re-shaping memory so that CREB comes out as Krebs cycle is
> > understandable, but what about "in rodents"? Possibly Kandel did speak
> > of his more recent mouse work, but maybe Aplysia was translated as "sea
> > hare" and the listener/viewer heard "hare", thought hares were still
> > classified as rodents, and therefore---!
> >
> > Of the 12 posters with Kandel's name somewhere among the authors (at
> > Society for Neuroscience a few weeks ago), only one of the Aplysia
> > abstracts included a reference to CREB (none of the mouse abstracts
> > did); CREB references in recent articles (4 yrs) in Medline were all in
> > Aplysia papers, except one mouse paper looking at something "downstream
> > from CREB-1". However, "CREB in rodents" may have been cited in that
> > program--did anybody see it? (i.e. any accurate reporters?)
> >
> > re my remarks about kkollins' willingness to speak on matters he
> > scarcely understands: please apply them to more appropriate occasions
> > past and future...
> >
> > F. Frank LeFever, Ph.D.
> > New York Neuropsychology Group
>> Sure, the reason you didn't find it is because the CREB stuff in the mouse
> wasn't done by Kandel it was done in Alcino Silva's lab (who I work for).
> The CREB mutant mouse (a mouse for which two of the major CREB isoforms
> have been knocked out) has a profound phenotype... it learns just about
> everything fine and then forgets it an hour or so later... it shows a
> similar pattern in synaptic plasticity. The CREB mechanism is conserved
> at least in drosophila, aplysia, and mice (and several others), so it is
> likely to work in humans. The problems of trying to make a drug out of it
> are profound, I won't go into this; if it does work, it will take many
> years to make it work.
>> Anyway try reading:
>> Silva et al. CREB and Memory. Annu Rev Neurosci. 1998;21:127-48.
>> Kogan et al. Spaced training induces normal long-term memory in
> CREB mutant mice.Curr Biol. 1997 Jan 1;7(1):1-11.
>> Bourtchuladze et al. Deficient long-term memory in mice with a targeted
> mutation of the cAMP-responsive element-binding protein. Cell. 1994 Oct
> 7;79(1):59-68
