Actually, neuromodulators do not react with G-proteins.
Ordinarily, they bind to specific receptor proteins in the membrane.
These receptors have extracellular binding sites specific to the
neuromodulator and intracellular binding sites specific to a G-protein.
When the neuromodulator binds to the receptor, the complex then
becomes capable of binding a G-protein.
There are other mechanisms through which modulators can work,
but this is the usual procedure.
What constitutes a "detailed" response depends on how much you
know about cellular/molecular biology. Do you want more?
George Little wrote in message ...
>Why do neuromodulators react with G-proteins before other substances?
>>A detailed response would be greatly appreciated.
>>> Thanks in advance.
>>