IUBio

Question re: neuromodulators.

Richard Norman rsnorman at mw.mediaone.net
Thu Nov 26 10:01:56 EST 1998


Actually, neuromodulators do not react with G-proteins.
Ordinarily, they bind to specific receptor proteins in the membrane.
These receptors have extracellular binding sites specific to the
neuromodulator and intracellular binding sites specific to a G-protein.
When the neuromodulator binds to the receptor, the complex then
becomes capable of binding a G-protein.

There are other mechanisms through which modulators can work,
but this is the usual procedure.

What constitutes a "detailed" response depends on how much you
know about cellular/molecular biology.  Do you want more?

George Little wrote in message ...
>Why do neuromodulators react with G-proteins before other substances?
>
>A detailed response would be greatly appreciated.
>
>
>                        Thanks in advance.
>
>





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