IUBio

NMDA receptor antagonists: Isogenic forms?

Matt Jones jonesmat at ohsu.edu
Fri Nov 13 13:20:37 EST 1998


In article <72f4du$5mt$1 at nnrp1.dejanews.com> , bjk at mblab.gla.ac.uk writes:
>Is there any evidence at the moment for isogenic variation of this receptor?

If by "isogenic" you mean that one gene can produce several different
types of receptor, then the answer is _yes_. The genes for at least some
of the NMDA subunits contain several coding "exons" that are spliced
together at the RNA stage, so that several different "splice variants"
can be translated into slightly different proteins. There are about 4
cassettes that can be mixed and matched in different combinations, so the
total number of different gene products possible is considerable.

Matt Jones



More information about the Neur-sci mailing list

Send comments to us at biosci-help [At] net.bio.net