Cambridge Healthtech Institutes
TRINUCLEOTIDE REPEATS
April 6-7, 1998 Hilton of Santa Fe, Santa Fe, New Mexico
Overview
Trinucleotide Repeats: Where Are We Now and Where Should We Be
Headed?
Dr. Jason Brandt, Johns Hopkins University (invited)
Approaches to Genome Analysis: An Update
Incyte Pharmaceuticals (invited)
Mechanism-Based Approaches to Drug Development for Triplet
Diseases
Dr. C.Thomas Caskey, Merck Research Laboratories
Model Systems
CTG Repeats Expand and Act as Length-Dependent Fragile Sites
in Yeast
Dr. Catherine H. Freudenreich, Princeton University
Androgen Receptor YAC Transgenic Mice Carrying (CAG)4,5
Alleles Show Trinucleotide Repeat Instability
Dr. Albert La Spada, University of Washington
Expansion of d(CAG)xd(CTG)y Heteroduplex Structures in
Escherichia coli Is Enhanced in an Endonuclease V Background
Dr. Michael Mitas, Oklahoma State University
Trinucleotide Repeats and Cancer
Microsatellite Instability as a Carcinogenetic Event
Dr. Stephen J. Meltzer, University of Maryland
The CAG Repeat in the Androgen Receptor Gene: Its Role in
Health and Disease
Dr. Phil Kantoff, Dana-Farber Cancer Institute
Diagnostics
Targeted Genomic and cDNA Differential Display of
Trinucleotide Repeat Constaining Fragments
Dr. Cassandra Smith, Boston University
PCR-Based Test for the Fragile X Trinucleotide Repeat
Dr. John Wages, PE Applied Biosystems
Methods for DNA Extraction from Serum for PCR Analysis
of CAG Repeats in the Androgen Receptor
Dr.William D. Figg, National Cancer Institute
Multicolor Genotyping of Repeats Using Capillary Array
Electrophoresis and the MegaBACE DNA Sequencer
Dr. Elaine Mansfield, Molecular Dynamics
Mass Spec Approaches for Analyzing Proteins Encoded by
Trinucleotide Repeats
Sequenome (invited)
Mechanisms of Pathology and Prospects for Therapeutics
Polyglutamine Expansion and Neurodegeneration: Search
for Candidate Genes, Role as Genetic Factor, and Prospects
for Therapeutics
Dr. Christian Neri, Fondation Jean Dausset CEPH
RNA Structure in Trinucleotide Repeats
Dr. James McClellan, University of Portsmouth
SCA2: Phenotypes, Interacting Proteins, and Subcellular
Localization
Dr. Stefan-M. Pulst, UCLA
The expansion of trinucleotide repeats is the underlying cause
of a growing number of neurodegenerative diseases, as well as
other disorders, such as certain cancers. Recent advances,
including the use of a number of model systems, have provided
insights into the mechanisms of pathology and point the way to
lines of inquiry aimed at developing therapeutics, as well as
more specific and efficacious diagnostics. Scientists interested
in trinucleotide repeats will find this meeting an invaluable
source of information about the latest developments in this
rapidly advancing field.
HOTEL INFORMATION
Hilton of Santa Fe Reservations made after the cut-off date
100 Sandoval will be accepted on a space and rate
Santa Fe, NM 87501 availability basis. Available rooms are
limited, so please book early.
T: 505-988-2811
F: 505-986-6439 Please identify yourself as a Cambridge
Cut-off Date: Healthtech Institute conference attendee
February 18, 1998 to receive the reduced room rate.
Room Rate: $115 single/double occupancy
TRAVEL INFORMATION
TRAVELWORLD T: 717-288-9311 or 800-828-6033
601 Market Street F: 717-288-4693
Kingston, PA 18704
Exclusive airline discounts are available on American Airlines as
well as other specific airlines when tickets are purchased through
TRAVELWORLD at least 14 days prior to the meeting date. Some
restrictions apply.
CALL FOR POSTERS
Cambridge Healthtech Institute encourages attendees to gain further
exposure by presenting their work in the poster sessions. Please fill
out the registration form, with the poster title and primary author.
To ensure inclusion in the conference binder, a one-page summary must
be submitted by March 6, 1998..
CALL FOR EXHIBITORS
Companies developing diagnostics or therapeutics for trinucleotide
repeat expansion diseases or offering such services should consider
taking advantage of this opportunity to reach highly targeted
international audience of senior researchers and managers most
involved in this field. Please contact Jim MacNeil of Cambridge
Healthtech Institute at 617-630-1341 to obtain an exhibitor package
or to inquire about offering a workshop during the meeting. Exhibit
space is limited, so call now to reserve a space at this event.
Each registration includes all conference sessions, posters and
exhibits, one luncheon and reception, continental breakfasts, all
refreshment breaks, and a copy of the document binder.
Handicapped Equal Access: In accordance with the ADA, Cambridge
Healthtech Institute is pleased to arrange for special accommodations
for attendees with special needs. All requests for such assistance
must be submitted in writing to CHI at least 30 days prior to the
start of the meeting.
Substitution/Cancellation Policy
In the event that you need to cancel a registration you may:
Transfer your registration to a colleague within your
organization.
Credit your registration to another Cambridge Healthtech
Institute program.
Request a refund minus a $75 processing fee.
Request a refund minus the cost ($195) of ordering a copy
of the document binder.
Cancellations will only be accepted up to one week prior to the
conference.
Program and speakers are subject to change.
------------------------Cut and Print Here------------------------
Yes! |__| Please register me for Trinucleotide Repeats 588 E
Academic, Government, Hospital-Affiliated
|__| Advance Registration (by February 27, 1998) $395
|__| On-site or Late Registration $445
Commercial
|__| Advance Registration (by February 27, 1998) $845
|__| On-site or Late Registration $945
FIRST NAME:______________________LAST NAME:__________________________
TITLE: __________________________DIV./DEPT.:_________________________
COMPANY:_____________________________________________________________
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|__| Please send information on exhibiting and opportunities to
present workshops.
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|__| MasterCard (16 digits)
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|__| Reserve with credit card information listed above and invoice
me. (Invoices must be paid in full by the deadline to retain
registration discount. Invoices unpaid one week prior to
conference will be billed to credit card at full registration
rate.) If you plan to register on site, please check with CHI
beforehand for space availability.
|__| I am interested in presenting a poster at Trinucleotide Repeats
and will provide an abstract by March 6, 1998.
Poster title:________________________________________________________
_____________________________________________________________________
FAX or MAIL your registration to:
Cambridge Healthtech Institute
1037 Chestnut Street
Newton Upper Falls, MA 02164
tel: 617-630-1300
fax: 617-630-1325