Dear all
In Alzheimer's disease,there are neuronal loss without neurofibrillary tangle
formation.
If you are interested in this problem,see;
Neurobiology of Aging 15,29-43,1994
Annals of Neurology 41,17-24,1997
These researches are based on numerical method.
"Astrocyte in Medicine"
Kenichiro Kashihara,M.D.