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BBB and Testosterone?

SG sg at NOWAYTOSPAMermine.ox.ac.uk
Mon Feb 9 13:33:32 EST 1998

 Mark R. Brink lic. phil.
 Swiss Federal Institute of Technology Zurich
 Institute for behavioral sciences

> Is it possible for Testosterone to pass the Blood-Brain Barrier? This
> is an important question when it comes to behavioral studies claiming
> direct nexii between the level of testosterone and certain kinds of
> behavior (e.g. aggression). 

Do not forget about possibility of indirect action. A chemical that
itself does not cross blood-brain barrier can still have an effect on
the brain by modulating release of endogenous agents. 

One example is nootropic drugs - some of them do not cross blood-brain
barrier but their effect depends on the function of adrenal glands.*

Sergei Gutnikov, D.Phil. (Oxon)
Department of Clinical Neurology
Oxford University

[*] showed by Cesare Mondadori (Switzerland), full reference to
published papers can be found in Medline

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