Ther Umsch 50 (3): 178-181 (1993)
Beta-carbolines (harman/norharman) are increased in heroin dependent
patients
Stohler R, Rommelspacher H, Ladewig D, Dammann G
Psychiatrische Universitatsklinik, Basel.
Endogenous substances resulting from interactions between alcohol and
possibly opioid metabolites and neurotransmitters (dopamine,
indolamines)
are mediators of the pathochemical process towards dependence.
Beta-carbolines are increased in alcoholics and--according to our own
results--in heroin-addicts. Still unclear is the impact of other
psychopathological disturbances like states of anxiety or depression;
unclear is also, if it has to be interpreted as state, trait or
residual
marker of the dependence syndrome.
MeSH Terms:
* Adult
* English Abstract
* Female
* Harmine/blood
* Harmine/analogs & derivatives*
* Heroin Dependence/rehabilitation
* Heroin Dependence/blood*
* Human
* Male
* Methadone/therapeutic use
* Substance Withdrawal Syndrome/blood
* Support, Non-U.S. Gov't
Substances:
* Methadone
* harman
* Harmine
* norharman
PMID: 8475471, MUID: 93235154
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