IUBio

Harman(e) increased in opiate addicts and alcoholics

Claude de Contrecoeur cyrano at twics.com
Wed Apr 16 08:31:12 EST 1997



Ther Umsch 50 (3): 178-181 (1993)

Beta-carbolines (harman/norharman) are increased in heroin dependent
patients

Stohler R, Rommelspacher H, Ladewig D, Dammann G

Psychiatrische Universitatsklinik, Basel.

Endogenous substances resulting from interactions between alcohol and
possibly opioid metabolites and neurotransmitters (dopamine,
indolamines)
are mediators of the pathochemical process towards dependence.
Beta-carbolines are increased in alcoholics and--according to our own
results--in heroin-addicts. Still unclear is the impact of other
psychopathological disturbances like states of anxiety or depression;
unclear is also, if it has to be interpreted as state, trait or
residual
marker of the dependence syndrome.

MeSH Terms:

   * Adult
   * English Abstract
   * Female
   * Harmine/blood
   * Harmine/analogs & derivatives*
   * Heroin Dependence/rehabilitation
   * Heroin Dependence/blood*
   * Human
   * Male
   * Methadone/therapeutic use
   * Substance Withdrawal Syndrome/blood
   * Support, Non-U.S. Gov't

Substances:

   * Methadone
   * harman
   * Harmine
   * norharman

PMID: 8475471, MUID: 93235154

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