IUBio

GHB receptors and Benzamide Neuroleptics

Claude de Contrecoeur cyrano at twics.com
Wed Apr 16 08:32:07 EST 1997



Eur J Pharmacol 256 (2): 211-214 (1994)

Displacement of [3H] gamma-hydroxybutyrate binding by benzamide
---------------------------------------------------------------------------------------------------------
neuroleptics and prochlorperazine but not by other antipsychotics.

----------------------------------------------------------------------------------------------------

Maitre M, Ratomponirina C, Gobaille S, Hode Y, Hechler V

Centre de Neurochimie, UPR 416 du CNRS, Strasbourg, France.

Since gamma-hydroxybutyrate receptor agonists exhibit dopaminergic
regulatory properties and neuroleptic-like effects in
neuropharmacological
tests, the common neuroleptics were tested for [3H]
gamma-hydroxybutyrate
binding activity on rat brain membranes. (-)-Sulpiride, sultopride,
amisulpride and prochlorperazine possess affinity for the
gamma-hydroxybutyrate site(s), consistent with their therapeutic
dosage.
This study has revealed that gamma-hydroxybutyrate receptors represent
an
additional target for antipsychotics.

MeSH Terms:

   * Animal
   * Antipsychotic Agents/pharmacokinetics*
   * Benzamides/pharmacokinetics*
   * Binding, Competitive
   * In Vitro
   * Male
   * Prochlorperazine/pharmacokinetics*
   * Rats
   * Rats, Wistar
   * Receptors, Cell Surface/metabolism*
   * Sodium Oxybate/pharmacokinetics*
   * Support, Non-U.S. Gov't

Substances:

   * Prochlorperazine
   * Sodium Oxybate
   * 4-hydroxybutyric acid receptor
   * Receptors, Cell Surface
   * Benzamides
   * Antipsychotic Agents

PMID: 7914168, MUID: 94326808

----------------------------------------------------------------------




More information about the Neur-sci mailing list

Send comments to us at biosci-help [At] net.bio.net