Eur J Pharmacol 256 (2): 211-214 (1994)
Displacement of [3H] gamma-hydroxybutyrate binding by benzamide
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neuroleptics and prochlorperazine but not by other antipsychotics.
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Maitre M, Ratomponirina C, Gobaille S, Hode Y, Hechler V
Centre de Neurochimie, UPR 416 du CNRS, Strasbourg, France.
Since gamma-hydroxybutyrate receptor agonists exhibit dopaminergic
regulatory properties and neuroleptic-like effects in
neuropharmacological
tests, the common neuroleptics were tested for [3H]
gamma-hydroxybutyrate
binding activity on rat brain membranes. (-)-Sulpiride, sultopride,
amisulpride and prochlorperazine possess affinity for the
gamma-hydroxybutyrate site(s), consistent with their therapeutic
dosage.
This study has revealed that gamma-hydroxybutyrate receptors represent
an
additional target for antipsychotics.
MeSH Terms:
* Animal
* Antipsychotic Agents/pharmacokinetics*
* Benzamides/pharmacokinetics*
* Binding, Competitive
* In Vitro
* Male
* Prochlorperazine/pharmacokinetics*
* Rats
* Rats, Wistar
* Receptors, Cell Surface/metabolism*
* Sodium Oxybate/pharmacokinetics*
* Support, Non-U.S. Gov't
Substances:
* Prochlorperazine
* Sodium Oxybate
* 4-hydroxybutyric acid receptor
* Receptors, Cell Surface
* Benzamides
* Antipsychotic Agents
PMID: 7914168, MUID: 94326808
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