IUBio

compartmental modeling of hippocampal pyramidal neuron

Michael Hucka hucka at eecs.umich.edu
Sun Apr 6 23:48:10 EST 1997


>>>>> On 27 Mar 1997, trullier at helios.ens.fr (Olivier Trullier) wrote:

  trullier> Hi, Does anyone know if there's a database available for building
  trullier> compartment models of pyramidal neurons (I'm especially
  trullier> interested in hippocampus), that is, web sites or detailed papers
  trullier> that describe lengths, diameters and interconnectivity pattern of
  trullier> the dendritic branches of a typical neuron, so that it can be
  trullier> mapped into an equivalent electrical circuit?

I believe several groups have done work along these lines.  James Bower is
the name that comes to mind.  His web page is:

    http://www.cns.caltech.edu/Faculty/Bower.html

If you are interested in this kind of work, the following book is
indispensable.  It contains some of the parameters you're seeking:

       EDITOR = {Christof Koch and Idan Segev},
	TITLE = {Methods in Computational Neuroscience},
    PUBLISHER = {MIT Press},
	 YEAR = 1989,
      ADDRESS = {Cambridge, MA}

There is a more recent book that looks useful for this topic, but I haven't
had a chance to look at it: _Large-Scale Neuronal Theories of the Brain_, by
Koch and Davis.  See the MIT Press web page for it:

    http://mitpress.mit.edu/mitp/recent-books/neuro/koclh.html

Of course, Wilfrid Rall and Idan Segev are the masters of cable theory and
compartmental models.  You may wish to find their articles if you haven't
already.  The Koch & Segev book also contain chapters by them.

-- 
Mike Hucka    hucka at umich.edu    http://www.eecs.umich.edu/~hucka    University
 PhD to be, computational models of human visual processing (AI Lab)     of
   UNIX systems administrator & programmer/analyst (EECS DCO)         Michigan



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