Gamma-Hydroxybutyrate:The First Sociabilising Molecule.
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The sociabilisers are a novel class of molecules, whose properties were discovered by
the author,and which could revolutionise the treatment of diverse psychopathologies.
In these psychopathologies I am including the high level of undesirable intra-specific
aggression found in the human species.
Man bas been unable to control his unwanted base-line paranoia and intra-specific
aggressivity even with such a powerful ideology such as Christianism.The sociabilisers
promise to reach,at last,such a control of these highly undesirable behaviours.
The future of mankind is in ENHANCING SOCIABILITY,first by sociabilising
molecules,then through a new science(not yet in existence)called
Neuromorphogenetics.The DEFINITIVE enhancement of sociability in man is a desirable
step for our descendants as this will promote cooperation between individuals instead
of a totally useless and destructive intra-specific aggression.Man has suffered since
his origin from his absurd intra-specific aggression,a heritage of his animal
origin,of his present-day bestiality
Intra-specific aggression should be eradicated in order to make "human" beings really
human beings and not sheer tallking and vociferous animals.The study of the
Sociabilisers is the first step in this important direction.
Christianism has failed to change the intra-specific aggression behaviour of man
because this very primitive behaviour is deeply entrenched in the human
CNS.Men(especially males and this applies equally to male scientists!)have a
propensity to aggress each other and to establish a pecking-order,like all animals.But
this primitive entropic behaviour is no longer in accordance with technological
societies.
In advanced technological societies we need highly sociable individuals.
Where,for obvious reasons,Christianism has failed,Science will,probably,succeed! When
intra-specific aggression will be only a foregone memory of the primitive Barbarians
we are just now,then we can predict a bright future to our descendants.
The discovery of the Sociabilisers is just,then,the beginning of a formidable
BEHAVIOURAL REVOLUTION.One day wars and misery will be seen only as the consequences
of a primitive faulty brain created by accident and not by a rational will.
The first sociabiliser was invented in France,in 1961:Gamma-OH or
gamma-hydroxybutyrate.Gamma-OH was invented by Laborit and Wermuth when Laborit was
thinking of creating a GABA analog which could penetrate through the brain-blood
barrier.He talked about this with Wermuth and Wermuth came with gamma-hydroxybutyric
acid.
At that time nobody knew that this discovery was potential gold for the study of human
behaviour and intra-specific aggression.
Three class of sociabilisers have been now defined:
1.Tyrosine Hydroxylase activators based on the prototypal Gamma-OH.
2.Tryptophan Hydroxylase inhibitors based on the prototypal M.D.M.A (3,4
Methylenedioxymethamphetmine).
3.Mixed Tyrosine Hydroxylase activators/Tryptophan Hydroxylase inhibitors.
This last class may represent powerful novel sociabilisers but this is not yet known.
Since the discovery of Gamma-OH,in France,the French were unable to classify this
molecule under anything known and so the classifiction of Gamma-OH has been rather
erratic!
It was,first,a hypnotic.Then it became a pre-anesthesiser and,now,it became an
anti-addictive medicine for alcoholism!!!
It may or may not become also an anti-addictive against opiate intoxication,as shown
in Italy.
After about 15 years of studying this molecule I,finally,arrived at the conclusion
that Gamma-OH was the first molecule in a serie of novel molecules to
be,correctly,called the SOCIABILISERS(Sociabilisants,en Français) because they act by
ENHANCING SOCIABILITY.
Experimenting both Gamma-OH and M.D.M.A,on myself and volunteers I,soon,discovered
that these two molecules had,subjectively,indistinguishable actions on sociability
though the sociabilising action of M.D.M.A is,first,masked because of its serotonin
releasing property
which is,subjectively,quite similar to the effects of fluvoxamine(the first specific
serotoninergic reuptake blocker which was,successfully,put on the market)on
consciousness and behaviour.
Gamma-OH (nicknamed "Or Potable" !!!),A Revolution for Mankind:On the Road to
Sociability
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Gamma-OH is a pure sociabiliser as its sociabilising effects are not hindered by other
antagonistic actions such as enhancement of serotoninergic neurotransmission.
Gamma-OH and M.D.M.A have been both classified under the novel concept of
Sociabilisers,together with the yet to be synthesised molecules sharing the properties
of both Gamma-OH and M.D.M.A which I,usually,nickname "Sociabiline" while
gamma-hyroxybutyrate has been nicknamed "Or Potable" because it is as precious as
gold,in my opinion,for mankind.
When human beings INTERACT ON INCREASINGLY FRIENDLY TERMS,natural base-line
paranoia,progressively,disappears to be replaced by a feeling of INTENSE
PLEASURE,which is the result of social interaction.
The lower natural paranoia becomes,the more sociability intensifies.Theory
demonstrates that such consciousness states as "love" or "mystical" states are only
states of exceedingly low paranoia and of,progressively,intensified sociability.
In fact,there seems to be a "circuit of paranoia" in the C.N.S which
would,both,generate paranoia and sociability,depending on how it is activated.
Hyperactivation of this system would generate paranoid states while hypoactivation
would generate sociable states,from love to mystical states.
It is thus hypothesised that depressing paranoia(naturally or
pharmacologically)leads,automatically,to increased sociability(probably through
oxytocinergic neuromediation,etc)while increasing paranoia(like with
pentazocine,phenylisopropylamines)leads to asociability and some psychopathologies
such as paranoid schizophrenia,etc.
Modulating the sociability states of human beings can represent a powerful
therapeuthics in depression and in the suppression of anxiety or suppression of the
negative symptoms of schizophrenia.
For instance,depression arises when SOCIABILITY IS DECREASED:intensifying sociability
will,thus,have a THYMOANALEPTIC(anti-depressant)effect.This is demonstrated by the
powerful thymoanaleptic properties of Gamma-OH.
Unfortunately,for depressed patients,and because of the imipraminomimetic dogma,the
thymoanaleptic properties of Gamma-OH remained,essentially,crypto-thymoanaleptic
properties until the author discovered the remarkable effects of gamma-hydroxybutyrate
on depression!
Sociabilisers will,probably,throw most SSRIs to the wastebasket once they are fully
developped!
How many lives could have been saved had the research on anti-depressants not stayed
confined on the invention of imipraminomimetics only.
The present working hypothesis on the mechanism of action of sociabilisers is that
they depress paranoia,as we noticed,thus leading,as natural sociability,to a vast
array of potentially useful therapeuthic effects.
