Hello,
I'm trying to develop a model of the non-linear hemodynamics
observed right before neurogenic pulmonary edema (or any case of massive
sympathetic stimulation). I'm trying to establish the relation between a
massive SNS discharge (due to CNS trauma) and vascoconstriction in the
CV system.
I'm trying to find out if there is any information available on
the relative innervation densities of various vascular components (large
arteries, arterioles, veins etc.) , and if there is a connection between
the innervation density and the extent of musculature in different
vascular components.
Does someone know of any studies (review compilation/otherwise) that
have, maybe, a table of relative innervation densities, or a table of
relative effects of sympathetic stimulation (quantised as say, reduction
in diameter, or increase in neurotransmitter levels) on vascular systems?
Are there also any studies on maybe "max. response" curves, of
sympathetic stimulation on vascular smooth muscle cells?
Responses of any kind, however marginal, will be GREATLY appreciated.
Thank you.
--
Madhusudan Natarajan
Biomedical Modeling and Controls Lab.
The University of Akron