We're currently considering the possability of infusing lidocaine (hydrochloride)
into rat brains for long term supression of localised neural structures (dorsal
caudate and hippocampas). In this case long term could range from 3 to 30
days. What we need to know is what are the likely consequences of such long
term infusion. Specifically; will the lidocaine continue to function effectively for
that length of time (how long is too long?), will long term exposure produce side
effects (eg. cell death, if so what period is 'safe'), will the cells recover normally
after long term exposure, what is the possability of colateral (antereograde,
retrograde) influence/damage, etc?
Any information at all would be greatly appreciated, as would any pointers for
finding any information.
Thanks
Mike Christie
Psyc. Dept.
Univ. Canterbury
Christchurch
New Zealand