Does anyone know if there exist yet an effective antisense
oligonucleotide targeted to the rat 5HT2A, 5HT2C and 5HT7 receptor? Maybe
any of you guys might give me some information about testing the
effectiveness of antisense oligo's against such receptors. I could try
ligand binding assays but this seems rather complicated (to far away from
the real process). I really want to show an antisense effect and I must
distinguish antisense effects from other effects such as up- and
downregulation, sequestration, toxicity...
Thanks anyway
Dirk Van Oekelen
tel:00 33(0)14 60 27 13
fax:00 33(0)14 60 53 80
email:dvoekele at janbe.jnj.com