IUBio Biosequences .. Software .. Molbio soft .. Network News .. FTP

New NOS inhibitors from Alexis Corporation

Dr. Stephen Hoare s.hoare at alexisuk.demon.co.uk
Sun Jan 21 11:01:03 EST 1996


ALEXIS CORPORATION has a wide range of NOS inhibitors, including a
number of new products which are specific for different isoforms of this
important enzyme, as shown in the summary table.

We are in the process of setting up a Web page with details of all our
catalogues, latest products, technical information, etc. In the
meantime, we plan to post selected information about new products to
relevant newsgroups. We would welcome your comments on the usefulness /
acceptability (or otherwise!) of this information (see 'Contacting
Alexis' following the Lit. References).

Product                 Cat. No.        Inhibitor of    Refs.
================================================================
NG-Amino-L-Arginine     106-014         eNOS, iNOS      1-4
S-(2-Aminoethyl)-ITU    270-030         iNOS            5-6
Aminoguanidine          420-004         cNOS, iNOS      7-12
3-Bromo-7-nitroindazole 270-009         bNOS            13
S-Ethyl-ITU             270-025         i,e,nNOS        5-6
L-NIL                   270-010         iNOS            14
L-NIO                   270-002         eNOS            15-18
S-Isopropyl-ITU         270-028         iNOS            5-6
1,3-PB-ITU              270-026         iNOS            5-6

For further information about these, or any other ALEXIS products for
Nitric Oxide research, see 'Contacting ALEXIS' below (following the
reference list).

LITERATURE REFS.
================
1.  J.M. Fukuto, K.S. Wood, R.E. Byrns and L.J. Ignarro; BBRC 168,
    458(1990)
2.  S.S. Gross, D.J. Stuehr, K. Aisaka, E.A. Jaffe, R. Levi and O.W.
    Griffith; BBRC 170, 96 (1990)
3.  H.M. Vargas, J.M. Cuevas, L.J. Ignarro and G. Chaudhuri; J.
    Pharmacol.Exp.Ther. 257, 1208 (1991)
4.  L. Lambert, J.P. Whitten, B.M. Baron, H.C. Cheng, N.S. Doherty and
    I. McDonald; Life Sci. 48, 69 (1991)
5.  E.P. Garvey, J.A. Oplinger, G.J. Tanoury, P.A. Sherman, M. Fowler,
    S.Marhsall, M.F. Harmon, J.E. Paith and E.S. Furfine; J.Biol.Chem.
    269, 26669 (1994)
6.  G.J. Southan, C. Szabo and C. Thiemermann; Br.J.Pharmacol. 114, 510
    (1995)
7.  J.A. Corbett, R.G. Tilton, K. Chang, K.S. Hasan, Y. Ido, J.L. Wang,
    M.A. Sweetland, J.R. Lancaster, J.R. Williamson, M.L. McDaniel; 
    Diabetes 41, 552 (1992)
8.  T.P. Misko, W.M. Moore, T.P. Kasten, G.A. Nickols, J.A. Corbett,
    R.G. Tilton, M.L. McDaniel, J.R. Williamson and M.G. Currie;
    Eur.J.Pharmacol. 233, 119 (1993)
9.  M.J.D. Griffith, M. Messent, R.J. MacAllister and T.W. Evans;
    Br.J.Pharmacol. 110, 963 (1993)
10. A.H. Cross, T.P. Misko, R.F. Lin, W.F. Hickey, J.L. Trotter and R.G.
    Tilton; J.Clin.Invest. 93, 2684 (1994)
11. G.A. Joly, M. Ayres, F. Chelly and R.G. Kilbourn; BBRC 199, 147
    (1994)
12. F. Laszlo, S.M. Evans and B.J.R. Whittle; Eur.J.Pharmacol. 272, 169
    (1995)
13. P.A. Bland-Ward, A. Pitcher, P. Wallace, Z. Gaffen, R.C. Babbedge
    and P.K. Moore; Br.J.Pharmacol. 112, 351P (1994)
14. W.M. Moore, R.K. Webber, G.M. Jerome, F.S. Tjoeng, T.P. Misko and
    M.G. Currie; J.Med.Chem. 37, 3886 (1994)
15. J.P. Scannell, H.A. Ax, D.L. Pruess, T. Williams, T.C. Demny and A.
    Stempel; J.Antibiot. 25, 179 (1972)/M. Palacios, R.G. Knowles,
    R.M.J. Palmer and S. Moncada; BBRC 165, 802 (1989)
16. D.D. Rees,R.M.J. Palmer, R. Schulz, H.F. Hodson and S. Moncada;
    Br.J.Pharmacol. 101,  746 (1990)
17. T. B. McCall, M. Feelisch, R.M.J. Palmer and S. Moncada;
    Br.J.Pharmacol. 102, 234 (1991)
18. M.S. Mulligan, S. Moncada and P.A. Ward; Br.J.Pharmacol. 107, 1159
    (1992)

CONTACTING ALEXIS
=================
For technical / ordering information:
ALEXIS US               TEL:  1-800-900-0065    or (619)658-0065
                        FAX:  1-800-900-9224    or (619)658-9224
ALEXIS SWITZERLAND      TEL:  +41(0)62 299 29 20
                        FAX:  +41(0)62 299 24 80
ALEXIS GERMANY          TEL:  +49(0)6401 900770
                        FAX:  +49(0)6401 3823
ALEXIS UK               TEL:  +44(0)1949 836111
                        FAX:  +44(0)1949 836222

For comments / suggestions, e-mail: s.hoare at alexisuk.demon.co.uk
-- 
Dr. Stephen Hoare
Alexis Corporation (UK) Ltd.
TEL: +44 (0) 1949 836111
FAX: +44 (0) 1949 836222



More information about the Neur-sci mailing list

Send comments to us at biosci-help [At] net.bio.net