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Opiate Dependance and Hippocampus

Zanos Stavros stavrosz at med.auth.gr
Wed Jan 17 20:31:13 EST 1996

In a relatively recent paper, Baloyannis et al. (1993) performed a 
morphological study (both under light and electron microscopy) of the CA1 
hippocampus region of 5 opiate users. They reported a substantial dilatation 
of the postsynaptic terminals, along with a marked decrease of the number of 
the synaptic vesicles in the presynaptic terminals and dilatation of the 
synaptic cleft, in the majority of the synapses. The light microscopy also 
revealed that numerous dendritic branches demonstrated a string of beads 
deformity, as well as a marked loss of dendritic spines.

Baloyannis et al. (1993) "Morphological Study of the Hippocampus in Opiate
	Users", Proc. 1st Hell. Conf. Drug Abuse Res., p. 282-294. University
	Studio Press, Thessaloniki, Greece.

Has anyone come across any references concerning electrophysiological/ 
molecular evidence of decreases in the capability of inducing LTP in 
morphologically normal/abnormal synapses on apical dendritic spines, in 
opiate users?

I am a 3rd year undergraduate medical student, and Im currently working on a 
project about the effects of opioid dependance on learning and memory, using 
data from molecular, morphological, physiological and computational 
approaches. I would much appreciate your help.

Zanos Stavros
Aristotle Univ Scholl of Medicine
Thessaloniki, Greece

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