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Melatonin and Growth Hormone

Dag Stenberg stenberg at cc.Helsinki.FI
Tue Jan 16 16:23:18 EST 1996


Dag Stenberg (stenberg at cc.Helsinki.FI) wrote:
} Dan Komaromi (komaromi at ucla.edu) wrote:
} } In my brief introduction to melatonin, I've heard reports that it
} } stimulates growth hormone.  Would this allow for any growth after an
} } organism's normal growth period, or simply increase the growth rate
} } during this period?

I addition to the studies I cited in my other message, there is a cell
culture study of the effects of melatonin (MEL) on tumor cell growth.
While prolactin and growth hormone increase tumor growth, MEL at
physiological tissue concentrations was able to block these effects, 
although it had no influence on tumor growth when used alone 
(Lemus-Wilson &al., Brit.J.Cancer 72:1435-1440, 1995). The conclusion 
was that the previously reported oncostatic activity of MEL could be
linked with an antagonism of the mitogenic activity of, especially,
prolactin. 

Dag Stenberg
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Dag Stenberg     MD PhD                    stenberg at cc.helsinki.fi
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