BLOOD PRESSURE & CARDIAC OUTPUT MEASUREMENT IN MICE & RATS
During the last decade, the production of transgenic mice, with different
gene expression provided a valuable tool for the study of genes involved
in cardiovascular functions in
recipient. In small animal, the hemodynamic measurement is very limited
because of the animal size. The most important and basic cardiovascular
parameters, considered by physiologists and pharmacologists, are cardiac
output, blood pressure, heart rate and stroke volume. Despite the plethora
of instruments currently available for studying the above mentioned
parameters in laboratory animals, no such instrument can measure all four
parameters simultaneously except CARDIOMAX-IIR. Thermodilution technique
in measuring cardiac output is most frequently used in human and in
different animals. A little information is available in measuring cardiac
output in mice. Recently, we have
established the measurement of cardiac output in mice by thermodilution
technique using CARDIOMAX-IIR. We injected a bolus of 15 ul of saline
(room temp.) through jugular vein to the vena cava and the resultant
change in temperature was measured in the arch of aorta. We found that
cardiac output in mice ranges between 10 and 12 ml/min. If you are
interested in receiving more information, please provide your street
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DR. GHOSH
PHYSIOLOGIST