On 4 Dec 1996, William Barnes wrote:
> Hello,
> I have been infusing solid drugs into the brain and have been having a
> hard time controlling the rate of diffusion of the drug through brain
> tissue. Does anyone have any comments to offer in this regard? Thanks.
> William Barnes
What do you mean "infusing solid drugs"? If you are depositing pellets,
there are a variety of binders that may be helpful to slow diffusion.
It's important to consider the solubility properties of the drugs - are
they lipophilic? Is there any way to covalently bind them to larger
molecules without altering their effects? By controllin, do you mean
that there is a lot of variability, or you'd prefer them to act only
locally? Are co-administering an inert marker with like solubility that
might allow you to "guestimate" the areas of diffusion? Would looking at
shorter exposure times help?
Just some thoughts,
Matt
_______________________________________________________
Matt Fraser "Hey, You! Don't help them
To bury the Light.
mof at prophet.pharm.pitt.edu Don't give in
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