UNSTABLE TRIPLETS, MICROSATELLITES,
AND HUMAN DISEASE
Organizers: Jack Griffith, University of North Carolina-Chapel Hill,
Robert Wells, Texas A&M University,
and David Nelson, Baylor College of Medicine
April 1-6, 1997; Santa Fe, New Mexico
Tuesday 4/1
2-7pm Registration
8-9pm KEYNOTE ADDRESS
C. Thomas Caskey, Merck & Company
Triplet Diseases: Past, Present and Future
Wednesday 4/2
7-8am Breakfast
8-11:30am WELCOME INTRODUCTION: UNSTABLE MICROSATELLITES:
MECHANISMS AT THE DNA LEVEL I
Jack Griffith, University of North Carolina-Chapel Hill
Welcome Introduction
Miroslav Radman, Institute Jacques Monod-FRANCE
Interplay Between SOS and Mismatch Repair Systems in Genome
(in)Stability and Evolution
Geoffrey Wahl, Salk Institute for Biological Studies
p53 Dependent Cell Cycle Responses to DNA Mismatches
Involving p53
Richard Fishel, Thomas Jefferson University
The Recognition of Mispaired Nucleotides, Microsatellite
Sequences and DNA Lesions by the Human Mismatch Repair
System
Stephen Thibodeau, Mayo Clinic
Microsatellite Instability in Colon Cancer
Michael Siciliano, University of Texas/MD Anderson Cancer Center
Factors Affecting Microsatellite Instability
1:30-3:30pm WORKSHOP: GENOME INSTABILITY AND REPAIR
MICROSATELLITE DNA STRUCTURE
7:30-10:30pm UNSTABLE MICROSATELLITES: MECHANISMS AT THE DNA
LEVEL II
Robert Wells, Texas A&M University
DNA Structure, Triplet Repeats, and Human Hereditary Diseases
Thomas Kunkel, National Institutes of Environmental Health Sciences
Studies of Replication Fidelity and Mismatch Repair of Repetitive
DNA Sequences
Sam Wilson, National Institute of Environmental Health Sciences
Where Errors Could Occur at the Level of Replication
Tom Petes, University of North Carolina-Chapel Hill
Microsatellite Instability in Yeast
Thursday 4/3
7-8am Breakfast
8-11:30am MICROSATELLITE CHROMATIN, TELOMERES, FRAGILE SITES,
AND THE FRAGILE X SYNDROME I
Jack Griffith, University of North Carolina-Chapel Hill
Microsatellite Chromatin: Properties and Pathology
Tom Glover, University of Michigan
Molecular Delineation of Common Fragile Sites
Titia de Lange, The Rockefeller University
Mammalian Telomeric Proteins
Virginia Zakian, Princeton University
Maintaining Saccharomyces Telomeres
Robert Richards, Womens and Childrens Hospital-AUSTRALIA
Molecular Genetics of Fragile Sites
1:30-3:30pm WORKSHOP: CHROMOSOME STRUCTURE AND FRAGILE X
MYOTONIC DYSTROPHY/FRIEDREICHS ATAXIA
7:30-10:30pm MICROSATELLITE CHROMATIN, TELOMERES, FRAGILE SITES,
AND THE FRAGILE X SYNDROME II
David Nelson, Baylor College of Medicine
The Fragile X Diseases
B. A. Oostra, Erasmus University-NETHERLANDS
Fragile X Syndrome and the Gene Involved
Stephen Warren, Emory University
Molecular Basis of Fragile X Syndrome
Walter Doerfler, University of Köln-GERMANY
On the Molecular Biology of the Fragile X Syndrome
Friday 4/4
7-8am Breakfast
8-11:30am MYOTONIC DYSTROPHY AND FRIEDREICHS ATAXIA: LOSS OF
FUNCTION MICROSATELLITE DISEASES AND CANCER I
Robert Korneluk, Childrenís Hospital of Eastern Ontario Research
Inst-CANADA
Myotonic Dystrophy (DM): Effect of the CTG Repeat Mutation on
Expression of the DM Kinase Gene
David Housman, Massachusetts Institute of Technology
Myotonic Dystrophy Kinase Gene Expression
B. Wieringa, University of Nijmegen-NETHERLANDS
The DM Locus in Mouse and Man: Genotype - Phenotype Correlations
Keith Johnson, University of Glasgow-UK
Is Myotonic Dystrophy a Polygenic Disorder?
Eric Hoffman, University of Pittsburgh School of Medicine
Myotonic Dystrophy: Evidence for a Dominant-Negative RNA Mutation
1:30-4:30pm MYOTONIC DYSTROPHY AND FRIEDREICHS ATAXIA: LOSS OF
FUNCTION MICROSATELLITE DISEASES AND CANCER II
Massimo Pandolfo, CRLS - Pavillon de Seve-CANADA
Friedreichs Ataxia
Carlo Croce, Thomas Jefferson University
Genetics of Human Cancer
Guillermina Lozano, University of Texas/MD Anderson Cancer Center
Cancer Predisposition in Li Fraumeni Syndrome
Charles Cantor, Boston University
New Approaches to Genome Analysis
8-10pm BANQUET
Saturday 4/5
7-8am Breakfast
8-11:30am CAG/POLYGLUTAMINE NEURODEGENERATIVE DISEASES:
GAIN OF FUNCTION? I
Jean-Louis Mandel, INSERM-University Louis Pasteur-FRANCE
Huntingtons Disease and Spinocerebellar Ataxia
Kenneth Fischbeck, University of Pennsylvania School of Medicine
Kennedys Disease
Marcy MacDonald, Massachusetts General Hospital
Huntingtons Disease
Harry Orr, University of Minnesota
Repeat Instability and Pathogenesis of SCA1 in Transgenic Mice
Gillian Bates, UMDS-Guys Hospital-UK
Huntingtons Disease Mouse Model
1:30-3:30pm WORKSHOP: POLYGLUTAMINE DISEASES: PATHOLOGY
POLYGLUTAMINE DISEASES: PROTEIN STRUCTURE
8-10:30pm CAG/POLYGLUTAMINE NEURODEGENERATIVE DISEASES:
GAIN OF FUNCTION? II
Akira Kakizuka, Kyoto University-JAPAN
Molecular and Genetic Bases of Machado-Joseph Disease
Christopher Ross, Johns Hopkins University School of Medicine
Huntingtons Disease and DRPLA
Jeffrey Vance, Duke University Medical Center
Haw River Syndrome
Sunday 4/6
DEPARTURE
How To Register:
Registration Fees will be based on the DATE Received in our office,
not the date postmarked. All checks must be drawn on a U.S. Bank
in U.S. Currency.
Abstract ONLY (by January 22, 1997)
Poster Abstract Submission Fee: $50
Abstract/Registration
(Send Abstract/Registration before January 22, 1997)
Registration Fee: $475 Student Fee: $350 Commercial: $600
Late or on-site Registration (Register after January 22, 1997)
Registration Fee: $575 Student Fee: $400 Commercial: $700
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Santa Fe, New Mexico Phone: 505-988-2811
Hilton of Santa Fe Fax: 505-986-6439
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The Hilton of Santa Fe: Single or Double: $575.00
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----PLEASE COPY AND PRINT OUT FROM HERE------------------------
CAMBRIDGE SYMPOSIA REGISTRATION FORM CS03-97
UNSTABLE TRIPLETS, MICROSATELLITES, AND HUMAN DISEASE
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