where do I mail the reply... maybe to spammer at sellout.eli.lilly.profit.com???
Fact is, Zoloft is *far more* selective than prozac... while prozac has
been arguably demostrated marginally better at improving depression than
Zoloft, and may be effective at lower doses for many forms of depression,
this is because of the slight norepinephrine boost that Prozac provides
and Zoloft does not!!! Zoloft is simply a drug that does its job too well.
What am I saying? that a patient who responds to Zoloft somewhat, but not
entirely, but receives nothing from a dosage increase of zoloft alone may
benefit ENOURMOUSLY from the addition of a small amount of Wellbutrin or
one of the TCA antidepressants. Why? Because they target other systems -
systems somewhat targeted by Prozac because Prozac is less selective.
My personal experience is totally different. I reacted to Imipramine
(alone) with severe paradoxical depression and no improvement in any
area. Prozac didn't do much for me either, but Zoloft curbs my
aggression/violent desires very well. Prozac is too jittery for me -
although with the way I take caffeine maybe its an interaction. Suffice
to say I disliked it. It wasn't stimulanty, but JITTERY, like muscle
tremors and stuff...
Anyways, enough spam... now for some biological stuff... a receptor
binding list(!!!) backing up what I said..
From: lamontg at u.washington.edu (Lamont Granquist)
Newsgroups:
sci.med.psychobiology,sci.med.pharmacy,alt.psychoactives,alt.drugs
Subject: SSRI Neurochemistry
Date: 10 Sep 1994 23:13:54 GMT
Message-ID: <34teji$f6t at news.u.washington.edu>
As mentioned in the original article, these drugs typically have active
metabolites which may be significant. Thus, actual in vivo activity may
be slightly different.
As mentioned in the original article, these drugs typically have active
metabolites which may be significant. Thus, actual in vivo activity may
be slightly different.
Receptor Affinities for SSRI drugs
(Values normalized to the IC50 for 5-HT reuptake)
[Data Taken from: Internatn-Clin-Psychopharm, 9 suppl 1: 19-26 (1994)]
Clomiprimine Fluoxetine Sertraline Paroxetine Fluvoxamine
(Anafranil) (Prozac) (Zoloft) (Paxil) (Luvox)
SRI: 1 SRI: 1 SRI: 1 SRI: 1 SRI: 1
NARI: 14 NARI: 54 NARI: 840 NARI: 280 NARI: 160
DARI: 2900 DARI: 740 DARI: 250 DARI: 18000 DARI: 11000
D1: 130 D1: 1500 D1: 33000 D1: 52000 D1: >26000
D2: 290 D2: 4700 D2: 130000 D2: 180000 D2: 17000
H1: 36 H1: 470 H1: 53000 H1: 66,000 H1: 2900
ACh: 45 ACh: 445 ACh: 5800 ACh: 720 ACh: 8900
S1A: 1900 S1A: 12000 S1A: >530000 S1A: >340000 S1A: >26000
S2A: 36 S2A: 100 S2A: 45000 S2A: 62000 S2A: 3200
S2C: n/a S2C: 235 S2C: n/a S2C: 69000 S2C: 1800
Alpha1: 40 Alpha1:2000 Alpha1:15000 Alpha1: 66000 Alpha1:1300
Alpha2:1200 Alpha2: 410 Alpha2: 9500 Alpha2:300000 Alpha2: 500
Beta: 15000 Beta: 264 Beta: 74000 Beta: 120000 Beta: 23000
Radioligands used in binding:
D1: SCH23390; D2: Spiperone; 5-HT1A: 5-OH-DPAT;
5-HT2A: Ketanserin; 5-HT2C: Ly278584; Alpha1: Prazosin;
Alpha2: Idazoxan; Beta: Dihydroalprenolol; H1: Mepyramine;
ACh: QNB.
[speaking of metabolites, paxil has none that are active, zoloft's
metabolite, while longer lasting is largely inactive, and Prozac's
metabolite, extremely long lasting, is half as potent - making
norfluoxetine the active drug!!!]