A studentship is available (from September 1995) for research
leading to a Ph.D. in the Neurotransmission Laboratory of the
Anaesthetics Unit.
The project
Cerebral ischaemia is a major cause of permanent debility. The
objective of this project is to determine the chronology of
transmitter release events during the early phase of ischaemia
and to establish the window of therapeutic opportunity using a r
eal-time transmitter measurement method in brain slices. The N
eurotransmission laboratory has established an in vitro method
to investigate cerebral ischaemia in striatal and cortical brain
slices that eliminates the temperature dependency observed in
vivo and thus allows neuroprotective effects to be characterised
independent of haemodynamic phenomena. The intention is to
establish the sequence of events that occur in this phase and
thus to elucidate mechanisms that may be amenable to
pharmacological intervention, particularly by those agents
used in clinical anaesthesia. The project is under the
supervision of Dr Jon Stamford.
How to apply
The successful candidate will be highly motivated and already
hold, or be expected to receive, at least an upper second in
pharmacology, physiology, biochemistry or a related discipline.
Application is by submission of full CV and 2 letters of reference,
at least one from a member of staff of the applicants
current department.
Further details from:
Mrs S. Stevens, (secretary) Anaesthetics Unit, London
Hospital Medical College, Alexandra Wing, Royal London
Hospital, Whitechapel, London E1 1BB. (Tel: 0171 377 7725) or
email Jon Stamford (j.stamford at lhmc.ac.uk)
Closing date: 31st July 1995