A studentship is available (from September 1995) for research
leading to a Ph.D. in the Neurotransmission Laboratory of the
Anaesthetics Unit.
The project
Cerebral ischaemia is a major cause of permanent debility. The
objective of this project is to determine the chronology of
transmitter release events during the early phase of ischaemia
and to establish the window of therapeutic opportunity using a
real-time transmitter measurement method in brain slices. The
Neurotransmission laboratory has established an in vitro method
to investigate cerebral ischaemia in striatal and cortical brain
slices that eliminates the temperature dependency observed in
vivo and thus allows neuroprotective effects to be characterised
independent of haemodynamic phenomena. The intention is to establish
the sequence of events that occur in this phase and thus to elucidate
mechanisms that may be amenable to pharmacological intervention, p
articularly by those agents used in clinical anaesthesia. The
project is under the supervision of Dr Jon Stamford.
The department
The Anaesthetics Unit combines clinical and fundamental research,
conducted by both basic scientists and clinical researchers. There
is a broad base of research interests within the department and
strong specialisation in specific areas such as in vivo
neurochemistry, novel muscle relaxants, and intensive care.
How to apply
The successful candidate will be highly motivated and already
hold, or be expected to receive, at least an upper second (or overseas
equivalent) in pharmacology, physiology, biochemistry or a related d
iscipline. Application is by submission of full CV and 2 letters
of reference, at least one from a member of staff of the
applicants current department.
Further details from:
Mrs S. Stevens, (secretary) Anaesthetics Unit, London Hospital
Medical College, Alexandra Wing, Royal London Hospital, W
hitechapel, London E1 1BB. (Tel: 0171 377 7725).Or email me at
j.stamford at lhmc.ac.uk
Closing date:
31st July 1995