In article <2tv2fd$q3 at alpha.epas.utoronto.ca> milton at spine.med.utoronto.ca (Milton Charlton) writes:
>From: milton at spine.med.utoronto.ca (Milton Charlton)
>Subject: Bradykinin blockers in clinic ??
>Date: 18 Jun 1994 15:05:17 GMT
>BRADYKININ BLOCKER: Do any clinically useful bradykinin blockers
>exist? Have there been clinical trials? Are any bradykinin blockers
>useful for topical application in hyperalgesia/ allodynia?
The German company Hoechst synthesized a bradykinin B2-antagonist (Icatibant,
code name: HOE-140) which is active against experimentally induced
pancreatitis in rats as well as in several animal models of inflammatory pain.
I heard it being tested against pancreatits in patients, but I don't know any
details.
Ulrike Holzer-Petsche
