In article <299neq$cme at charm.magnus.acs.ohio-state.edu>,
Michael I Sandstrom <misandst at magnus.acs.ohio-state.edu> wrote:
>> I am looking for references regarding the PC-12 cell line. What
>is the history of this line? Where did these cells come from? What does
>in-vitro electrophysiology et cetera really tell us about the neuron
>of the CNS? Is this cell line capable of much differentiation? Someone
>please direct me to the appropriate literature (review papers etc.).
>Thanks in advance!
>
The PC12 cell line was isolated by Lloyd Greene and Steven Tischler from
a rat pheochromocytoma. Upon addition of NGF, PC12 cells assume a sympathetic neuronal-like phenotype. I think the relevant paper appeared in PNAS in
1976.
......................................................................
. o \ o / _ o __| \ / |__ o _ \ o / o .
. /|\ | /\ ___\o \o | o/ o/__ /\ | /|\ .
. / \ / \ | \ /) | ( \ /o\ / ) | (\ / | / \ / \ .