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Postdoctoral position in Bioinformatics / Computational Biology.

Arne Elofsson arne at rune.biokemi.su.se
Sun Feb 9 16:58:10 EST 1997


Postdoctoral position in Bioinformatics / Computational Biology.

Analysis and prediction of membrane protein structures.

Applicant are invited for a 2-year postdoctoral fellowship at the
University of Stockholm, Department of Biochemistry in the groups of
Professor Gunnar von Heijne and Associate Professor Arne Elofsson
(This applications can also be found at
http://www.biokemi.su.se/~arne/postdoc_vt97/ )

		The Project

The number of membrane proteins with known 3D structure has increased
recently and a number of hypotheses about membrane protein structure can
now be tested. The goal of the project is to analyze known 3D structures
and derive rules that can be used for structure prediction of membrane
proteins. These studies will be performed in close contact with
experimental studies performed in the group of Gunnar von Heijne.


		The applicant

We are looking for a person with a Ph.D in life science / computer scienc=
e
/ bioinformatics with experience of working in an UNIX environment.
Programming experience and experience of sequence analysis / molecular
modeling / structural biology is desired.


		The group

The biocomputing group presently consists of five people: three graduate
students, one assistant professor (Arne Elofsson), and one full professor
(Gunnar von Heijne). The group of Gunnar von Heijne uses both experimenta=
l
and theoretical techniques to study membrane protein assembly and
structure. The group of Arne Elofsson also works on ab initio protein
folding studies, threading / fold-assignments, and homology modeling.

The computing environment is based on local UNIX workstations and we also
have access to the Swedish National Supercomputer Center in Stockholm. We
have close collaborations with several groups both in Sweden and abroad.


		Recent Papers

"Local moves, an efficient method for protein folding simulations" Arne
Elofsson, Scott Le Grand & David Eisenberg, 1995 Proteins, Structure
Function and Genetics 23:73-82

Wallin, E., and von Heijne, G. (1995) Properties of N-terminal tails in
G-protein coupled receptors - A statistical study. Protein Engineer. 8,
693-698.

Nielsen, H., Engelbrecht, J., von Heijne, G., and Brunak, S. (1996)
Defining a Homology Threshold for a Functional Protein Sequence Pattern:
The Signal Peptide Cleavage Site. PROTEINS: Struct. Funct. Genet. 24,
165-177.

Nielsen, H., Engelbrecht, J., Brunak, S. and von Heijne, G. (1997) A neur=
al
network method for identification of prokaryotic and eukaryotic signal
peptides and prediction of their cleavage sites. Prot.Engineer., 10, 1-6.

Recent advances in how to test knowledge based energy functions for prote=
in
folding studies." Arne Elofsson, 1997 in press in "Recent Research
Developments in Physical Chemistry"

"Prediction of transmembrane alpha-helices: Application of the Dense
Alignment Surface method" Miklos Cserz=F6, Erik Wallin, Istvan Simon, Gun=
nar
von Heijne, Arne Elofsson, 1996 submitted.

"Architecture of helix bundle membrane proteins. An analysis of Cytochrom=
e
c oxidase from bovine mitochondria.", Erik Wallin, Tomotake Tsukihara,
Shinya Yoshikawa, Gunnar von Heijne, Arne Elofsson, 1997 in press in
Protein Science


For more information, please contact:
Arne Elofsson (arne at biokemi.su.se; http://www.biokemi.su.se/~arne/)

or

Gunnar von Heijne (gunnar at biokemi.su.se; http://www.biokemi.su.se/~gvh/)





--=20
-----------------------------------------------------------------
 Arne Elofsson     arne at bimbo.biokemi.su.se http://www.biokemi.su.se/~arn=
e/
 Tel:+46(0)8-161553      Dep, of Biochemistry, Stockholm University
 Fax:+46(0)8-153679	 10691 Stockholm, Sweden



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