Why is Streptomycin less effective against gram-positive bacteria?

Jenny Gibbs JennyGibbs at Sheffield23.fsnet.co.uk
Wed Apr 13 14:48:37 EST 2005

I'm an A-Level Biology student and am in the middle of a Microbiology 

I had to research and compare the effectiveness of Streptomycin against a 
gram positive (Staphylococcus albus) and a gram-negative (E.coli) bacteria. 
I found that Streptomycin was significantly more effective against the 
gram-negative strain, a pattern supported by background research.  I know 
that Streptomycin works by inhibiting protein synthesis but can't see why 
this would be more effective against gram negatives than gram positives, 
particularly given the fact that gram-negatives have the second outer 
membrane to inhibit the entry of chemicals into a cell.
Can anyone help please?
I will make due reference to any help in the Bibliography section of the 
Many thanks.

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