IUBio

How long is a protein sequence?

Scott Coutts scott.coutts at med.monash.edu.au
Thu Dec 2 06:09:42 EST 2004


Stefek Borkowski wrote:
> Hi,
> Can someone explain how the length of protein sequence, i.e. the number 
> of amino acid residues, should be properly counted. I try to assess the 
> length of human heart fatty acid binding protein. It is physically built 
> of 133 amino acids, but for some reason the literature value is 132. It 
> seems like the paper purposely omits the first methionine. Also the 
> numbering of amino acids goes this way, as if the starting methionine is 
> not present. Would you please comment on this. Thank you in advance. 
> Regards,
> Stefek

Sometimes the first amino acid is removed proteolytically after the 
protein is produced.

Scott.



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