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The Drug DNP

Eric R. Hugo eric.hugo at uc.edu
Fri Oct 11 23:12:05 EST 2002

DNP is an electron transport uncoupler.  It wipes out the H+ gradient 
across the mt inner membrane thus preventing ATP synthesis.  Instead all 
the energy the cell has extracted from glucose, fatty acids, etc. is 
released as heat.  This is the same principle as what occurs in brown fat 
which is found in infants.  In the case of brown fat the cells make a 
special protein to uncouple electron transport.

"Carlos V" <srcarlosvelez at hotmail.com> wrote in
news:aR8p9.33106$0o4.9827 at sccrnsc03: 

> This question might be a little out of the ball park for this group,
> but I thought I would give it a shot.
> I'm trying to do a research project on the drug DNP (Dinitrophenols)
> that was perscribed in the '30s and '40s for weight loss.
> This durg makes the mitochondrial membrames leaky to hydrogen ions. 
> (Not being a biology major, I have to ask)  Why would a leaky
> mitochondrial membrane cause weight loss?  Would that speed up the ATP
> production? 
> What were the effects of this drug?

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