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? re complementary drug resistance patterns

Dr. S. Shapiro toukie at zui.unizh.ch
Mon Jan 7 09:55:19 EST 2002

Dear Colleagues,

     In the recent article "Combination antiviral therapy: but which
combination, andwhy?" [Curr. Opin. Infect. Dis. 13: 621-623 (2000)],
complementary drug resistance patterns are discussed, in terms of
instances where reduced drug susceptibility to one drug may enhance
the activity to another related drug.  As an example, the author says that
when a zidovudine-resistant HIV strain also becomes resistant to lamivudine,
the resulting virus appears to be REsensitised to zidovudine.  Likewise,
for some HIV protease inhibitors, some multi-potease resistant 
viruses apear to become hypersensitive to still another protease
inhibitor, amprenavir.

     Does anyone know of a corresponding phenomenon in antibacterial
and/or antifungal chemotherapy, i.e. an example of a bacterium or fungus
which has become resistant to antibiotic A develops a resistance to related
antibiotic B, as a result of which that bacterium or fungus becomes sensitive
again to antibiotic A?  Kindly share your responses with me _directly_ at

toukie at zui.unizh.ch

and please provide concrete examples and references if available.

Thanks in advance to all responders,

S. Shapiro
toukie at zui.unizh.ch

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