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P.aeruginosa and azithromycin

James Lovering james.lovering at pei.sympatico.ca
Mon Sep 10 13:51:08 EST 2001

Can you help, please?

The literature contains several references to the use of azithromycin to
‘reduce' P. aeruginosa's virulence factors and so lessen tissue damage. 
The P aeruginosa is not killed.  

Does the ‘reduction' of virulence factors imply a reduction in the
ability of the bacteria to grow and multiply?  If so does this open the
way to selection of the strains less affected and thus to resistance? 



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