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inflammatory response

univie a9071209 at unet.univie.ac.at
Tue May 29 06:34:23 EST 2001


Frederic Langlois <ye.midget.pirates.deleted.my.account at the.seven.seas>
schrieb in im Newsbeitrag: 9fkB6.14725$up4.1236428 at carnaval.risq.qc.ca...
> Hello! I'd like to know what triggers the inflammatory response when a
> bacteria infects an host. I'm trying to figure out the order the host and
> the immune system respond.
>
 I would say that PAMPs (pathogen-associated molecular patterns) plays a
great role in recognizing bacteria infects.
These receptors are able to recognize special glycoproteins, which are only
found on bacteria cell. They are in fact not really antigen- or epitop-
specific like an antibody, but they are really able to recognize bacteria
cell (An antibody doesn't have this ability!!!) So you can say that these
receptors are bacterial-specific. The second thing is, that these recoptor
does trigger the expression of second signals like B7.1 or B7.2 (CD80,
CD86), which are needed for an activation at the antigen-presentation
process.
You can read a new publication in nature about Toll-like receptor 5 - Nature
2001 Apr 26;410:1099-103.
You can also look in the Medline after review-articles from Janeway C Jr. He
invented the word PAMP and you will find articles about innate immune
recognition. I have read all that stuff but I have forgotten many of them

Genya Yanagida





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