National University of Mexico (Mexico City)
Biomedical Research Institute
The research group of Dr. Jorge Membrillo-Hernández at the Biomedical
Research Institute will start
working by August 2000. At this point we are looking for undergraduate or
graduate (MSc or Ph.D)
students and a Post-doct interested in the Molecular Biology and Genetic
Regulation of the response to oxidative and nutritional streeses in
bacteria. If you are interested please contact Dr. Membrillo-Hernández at
the following address: jmh at hms.harvard.edu
Examples of recent publications:
1 : Membrillo-Hernandez J, Lin EC. Regulation of expression of the adhE
gene, encoding ethanol
oxidoreductase in Escherichia coli: transcription from a downstream
promoter and regulation by Fnr
and RpoS. J Bacteriol. 1999 Dec;181(24):7571-9.
2 : Membrillo-Hernandez J, Kwon O, De Wulf P, Finkel SE, Lin EC. Regulation
of adhE (encoding
ethanol oxidoreductase) by the Fis protein in Escherichia coli. J
Bacteriol. 1999
Dec;181(23):7390-3.
4 : Membrillo-Hernandez J, Coopamah MD, Anjum MF, Stevanin TM, Kelly A,
Hughes MN, Poole
RK. The flavohemoglobin of Escherichia coli confers resistance to a
nitrosating agent, a "Nitric oxide
Releaser,"and paraquat and is essential for transcriptional responses to
oxidative stress.
J Biol Chem. 1999 Jan 8;274(2):748-54.
5 : Membrillo-Hernandez J, Coopamah MD, Channa A, Hughes MN, Poole RK. A
novel mechanism
for upregulation of the Escherichia coli K-12 hmp (flavohaemoglobin) gene
by the 'NO
releaser', S-nitrosoglutathione: nitrosation of homocysteine and modulation
of MetR binding to the
glyA-hmp intergenic region. Mol Microbiol. 1998 Aug;29(4):1101-12.
6: Membrillo-Hernandez J, Cook GM, Poole RK. Roles of RpoS (sigmaS), IHF
and ppGpp in the
expression of the hmp gene encoding the flavohemoglobin (Hmp) of
Escherichia coli K-12. Mol
Gen Genet. 1997 May 20;254(5):599-603.
7 : Membrillo-Hernandez J, Kim SO, Cook GM, Poole RK. Paraquat regulation
of hmp
(flavohemoglobin) gene expression in Escherichia coli K-12 is SoxRS
independent but modulated by
sigma S. J Bacteriol. 1997 May;179(10):3164-70.
If you are interested please send your CV and the names of three referees to:
jmh at hms.harvard.edu
Applications will be accepted until candidates are chosen.
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