Penicillin: A Paradigm for Biotechnology
Richard I. Mateles, Editor
Reprints The History of Penicillin Production, the classic publication of
the American Institute of Chemical Engineers, originally published in 1970
and long out-of-print. It is updated by the inclusion of two new chapters
dealing with scientific advances in penicillin biochemistry, microbiology,
and genetics made since 1970; and the current commercial and industrial
status of penicillin and its derivatives.
This book tells the remarkable story of penicillin’s progress from a
laboratory curiosity to being the first antibiotic available for regular
use, and still a very important product today. The contributors to this
book are the scientists and engineers who played the major role in that
enterprise, which has served as a model for fermentation development for the
last fifty years.
Among the penicillin program’s "firsts," which continue to be important in
biotechnology today, were:
mutation and selection for microbial strain improvement
scale-up of fermentors for aerobic processes
countercurrent liquid-liquid extraction
industrial-scale lyophilization of sterile pharmaceuticals
Published: December, 1998 xi + 114 pp. ISBN 1-891545-01-9
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