Possible degradation in the effectiveness of antibiotics in the treatment of human diseases

John P. Hegarty jph10 at psu.edu
Fri Jul 16 14:54:52 EST 1999

>Graham Shepherd <muhero at globalnet.co.uk> wrote
> I seem to remember that metronidazole can be used for amoebic dysentery,
> Why these drugs work is a mystery to me; the sulfa combination is supposed
> to block folate metabolism in bacteria. Presumably we have an alternative
> pathway; I guess some protozoans don't have it and that makes them


Check out the following article (this month's issue of AAC):
J. Samuelson. (1999) Why metronidazole is active against both bacteria and
Antimicrob. Agents Chemother. Jul;43(7):1533-41.



John P. Hegarty
Penn State - EMRL
Helicobacter Research

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