>Graham Shepherd <muhero at globalnet.co.uk> wrote
> I seem to remember that metronidazole can be used for amoebic dysentery,
too.
> Why these drugs work is a mystery to me; the sulfa combination is supposed
> to block folate metabolism in bacteria. Presumably we have an alternative
> pathway; I guess some protozoans don't have it and that makes them
susceptible.
Graham,
Check out the following article (this month's issue of AAC):
J. Samuelson. (1999) Why metronidazole is active against both bacteria and
parasites.
Antimicrob. Agents Chemother. Jul;43(7):1533-41.
-John
___________
John P. Hegarty
Penn State - EMRL
Helicobacter Research
http://www.personal.psu.edu/jph10
