Roberto A. GEREMIA geremia at cermav.cnrs.fr
Fri Oct 30 10:54:58 EST 1998


Centre de Recherches sur les Macromolécules Végétales (CERMAV/CNRS)
BP 53 - 38041 Grenoble cedex 9 - France

A post-doctoral position supported by the French Minister of Foreign Affaires
(Chautebriand fellowships) is open at our Center to work in the biochemical and
structural characterization of the Neisseria meningitidis ? (1-3)
N-Acetylglucosaminyltransferase LgtA. This protein shares sequence similarity
with other bacterial and human glycosyltransferases. LgtA is involved in the
synthesis of the lacto-N-neotetraose moiety of lipo-oligosaccharide (LOS). LOS
was found to be relevant for pathogenesis. The goal of the research is to
understand the molecular basis of this particular protein-sugar interaction, and
eventually design inhibitors.

The project consists in:
* Production of a recombinant form of the protein
* Biochemical characterization of the recombinant form of LgtA: kinetic
constants, study of possible inhibitors (acceptor and donor analogs).
* Role of conserved amino acids: site-directed mutagenesis, biochemical and
biophysical characterization of the mutants.
* Structural characterization.

The candidate should hold a Ph.D. on Biochemistry or Microbiology, and be a
Canadian citizen.

Please e-mail or fax CV to:
Roberto A. GEREMIA
E-mail: geremia at cermav.cnrs.fr
Fax: (foreign countries)

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