Dynamics, Structure and Function of Biological Macromolecules
4th Course of the International School of Structural Biology and Magnetic
Resonance - a NATO Advanced Study Institute
Location: Ettore Majorana Centre for Scientific Culture, Erice, Italy
Dates: May 25-June 5, 1999
Number of working days: 10 days
Objective: To summarize the current state of the field of protein studies
focusing on the type of information that can be obtained about dynamic
processes in proteins by NMR and other physical methods and the implications
for protein and drug design.
Fee: $1,200 includes Board and Lodging to be arranged by the Centre. Some
financial aid available and any request for aid should be indicated in the
application. Full support will NOT be available, so please indicate the
specific amount of financial aid necessary to attend.
Directors:
-Oleg Jardetzky, Professor, Department of Molecular Pharmacology,
Stanford University School of Medicine, Stanford, CA 94305-5337, USA.
Tel: (+1) 650/723-6153, Fax: (+1) 650/723-2253, Email:
jardetzky at stanford.edu
-Jean-Francois Lefevre, Professor, ESBS, Louis Pasteur University,
Bld. Sebastien Brant, 67400 Strasbourg-Illkirch, France.
Tel: (+33) 388 65 52 69, Fax: (+33) 388 65 53 43, Email:
lefevre at bali.u-strasbg.fr
To apply contact Course Registrar: Ms. Robin Holbrook
Fax: (1) 650/723-3353
Tel: (1) 650/723-6270
Email: reh at stanford.edu
URL: http:// www-leland.stanford.edu/~reh/Erice*99.html
No application form is required but applicants must submit:
1) date and place of birth and nationality
2) degree and other academic qualifications
3) list of publications
4) present position and work address, fax and phone numbers and email address
Young applicants with only a few years of experience in the field should
arrange for a letter of recommendation from the head of their research group.
Applicants interested in financial aid should also send an abstract of
current research interest. Selected papers will be presented in poster
sessions and student workshops.
APPLICATION DEADLINE: MARCH 15, 1999. A letter of acceptance will be sent to
successful applicants.
Lecturers
Cheryl H. Arrowsmith (Ontario Cancer Institute, Toronto, Canada)
Ivano Bertini (Universita degli Studi di Firenze, Italy)
Richard R. Ernst (ETH Zentrum, Zurich, Switzerland)
Hans Frauenfelder (Los Alamos National Laboratories, USA)
Cornelius W. Hilbers (University of Nijmegen, The Netherlands)
Oleg Jardetzky (Stanford University, USA)
Jean-Francois Lefevre (Universite Louis Pasteur, France)
Michael Levitt (Stanford University, USA)
William N. Lipscomb (Harvard University, USA)
Dino Moras (Universite Louis Pasteur, France)
Joseph D. Puglisi (Stanford University, USA)
Paul Rosch (Universitat Bayreuth, Germany)
Brian D. Sykes (University of Alberta, Edmonton, Canada)
Wilfred van Gunsteren (ETH Zentrum, Zurich, Switzerland)
Course Topics
EXPERIMENTAL OBSERVATION OF MOLECULAR MOTIONS
*Modern NMR techniques: 3D spectroscopy and molecular dynamics
*Protein crystallography
*Multisubunit allosteric proteins
OBSERVATION OF INTERNAL MOTIONS OF BIOLOGICAL MOLECULES
*Dynamics and conformational transitions in allosteric proteins
*Principles of NMR and dynamics
*Protein dynamics and reactions
*The energy landscape of proteins
THEORETICAL ANALYSIS OF INTERNAL MOTIONS IN BIOLOGICAL MOLECULES
*Introduction to molecular dynamics
*Simulations of protein folding
*Simulating protein and nucleic acid molecular dynamics
*New programs in MD simulations
*Calculation of free energy and binding constants
MOTIONS IN NUCLEIC ACID
*Nucleic acids structure and dynamics
*RNA NMR spectroscopy
ANALYSIS OF SPECIFIC PROTEINS
*Interactions of antifreeze proteins with ice
*Mechanism of action of calcium-signaling proteins
*tat-Protein structure, dynamics and function
*Protein-DNA complexes: Heteronuclear strategies of the assignment of larger
complexes
